Over the last few days, I've inadvertently been on a bit of a Henry Fonda spree. It started with Fort Apache (1948) before moving to The Lady Eve (1941) and then culminating into watching Once Upon a Time in the West (1968) again.
Of course, in that superb Sergio Leone film, Fonda plays the heinous, murdering Frank in one of the most inspired bits of against-typecasting that I've ever seen, and it's absolutely a career highlight.
Here's Fonda's entrance in Once Upon a Time in the West, which would be considered the greatest scene in the film if it wasn't preceded by one of the greatest opening titles sequences of all-time. (Notice the phenomenal sound design in this scene, as well.)
And here's Fonda in a 1975 talking about getting the role of Frank: