Those two films are good early works, but where they are optimistic, god-loving and reverently sympathetic, Manhattan Melodrama is hands-off and favorably indecisive. I'm strictly speaking of endings here, because in my opinion, Angels With Dirty Faces is a more lived-in and gritty film through 80 minutes before it takes a turn for the worst in the final few scenes.
I just prefer that whole Clark Gable sacrificial, unyielding move at the end of the film ("die the way you live") which so beautifully resembles the last hours of the life of John Dillinger - a point made clear by Michael Mann at the end of Public Enemies ('09). This is opposed to the jolly and flowery final moments to San Francisco and Angels With Dirty Faces which closely resemble the holy and pure mentalities prevalent in the films of the early Hollywood studio system.
Manhattan Melodrama may be a bit more rough around the edges and feel way to boxed-in and claustrophobic with its dark interiors, but it gets my vote over those two films because it doesn't completely succumb to the expected outcome. Both Clark Gable's Blackie Gallagher and William Powell's Jim Wade stand their ground and that kind of blurry line between right and wrong, in the end, makes the film work.